Burnside-butler syndrome. Figure 1. 15q11.2 BP1-BP2 microdeletion (Burnside Butler) syn...

Abstract: The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syn

The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most com-mon cytogenetic finding in patients with neuro... Journal Article OPEN ACCESS Genomic, clinical, and behavioral characterization of 15q11.2 bp1-bp2 deletion (burnside-butler) syndrome in five familiesBurnside Butler syndrome or 15q11.2 microdeletion syndrome is a relatively rare chromosomal abnormality that is recently being recognized. Current diagnostic techniques like chromosomal microarray analysis (CMA) have profoundly contributed to currently reported cases. The diagnostic dilemma is that prenatalParent of origin effects have been reported in Burnside–Butler syndrome (15q11.2 BP1–BP2 deletion) involving four genes and single imprinted gene conditions, Schaaf–Yang syndrome (MAGEL2) and central precocious puberty 2 (MKRN3); both genes paternally expressed and located in the chromosome 15q11-q13 region [13,20–24].BP1-BP2 region due to a deletion designated as Burnside-Butler syndrome, emerging with variable clinical findings including a neurodevelopmental-autism nondysmorphic phenotype with low penetrance.Europe PMC is an archive of life sciences journal literature. https://orcid.orgFeb 21, 2023 · Burnside–Butler syndrome is associated with motor and developmental delays, neurobehavioral problems including dyslexia, autism and psychosis with reported congenital anomalies [7,9]. Several of these findings are common in PWS, more so in those with the larger typical deletion. The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most com- mon cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for ...Abstract: The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most com-mon cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome includeThe 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes. Rafi SK, Butler MG Int J Mol Sci 2020 May 6;21(9) doi: 10.3390/ijms21093296.port to Butler et al. s findings of the phenotypic difference between type I and type II deletions [20,21]. The solitary BP1-BP2 deletion, or Burnside Butler Syndrome, is charac-terized by intellectual disability and various neuropsychiatric disorders. Figure 1. Genes in the PWS critical region, chromosome 15q11.2-q13. Created with BioRender.comAn emerging disorder that shares genetic components with PWS is now recognized as the 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome. The 15q11.2 BP1-BP2 region contains four genes in common with those with PWS having a typical chromosome 15q11-q13 deletion and will be discussed later in this review.(Rafi & Butler, 2020). The alteration of these pathways can be an explanation for neurobehavioural disturbances and dysmorphic features in individuals with B1-B3 deletion (PWS/AS typical type I deletion) and BP1-BP2 CNV (Burnside-Butler syndrome). However, BP1-BP2 CNVs are characterised by incomplete penetrance and variable ...Individuals with the 15q11.2 BP1-BP2 microdeletion or Burnside-Butler syndrome are known to have developmental and speech delay involving the CYFIP1 gene with an increased rate of aberrant behavior and autism . 4. Experimental Section ... Merlin G. Butler conceived the study, analyzed data and wrote the manuscript. Syed K. Rafi reviewed ...Individuals with a microdeletion of the 15q11.2 BP1-BP2 region or Burnside-Butler susceptibility locus can present with a wide range of clinical findings including intellectual …syndrome (AS), an entirely different clinical disorder [ 7, 8]. About two-thirds of individuals with PWS have a de novo Abstract Introduction Prader-Willi syndrome (PWS) is a mul-tisystemic complex genetic disorder caused by lack of expression of genes on the paternally inherited chromo-some 15q11.2-q13 region. There are three main geneticThe 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome include developmental and motor delays, congenital abnormalities, learning and ...The results of this study will help to better understand the molecular intricacies of the Burnside-Butler Syndrome and also the possible involvement of these interactions in the disease aetiology ...The 15q11.2 BP1–BP2 microdeletion (Burnside-Butler) syndrome is now a recognized condition with over 200 individuals identified from the literature using chromosomal microarray analysis. Clinically, neurological dysfunction, developmental and language delay are the most commonly associated findings followed by motor delay, …Genomic, Clinical, and Behavioral Characterization of 15q11.2 BP1-BP2 Deletion (Burnside-Butler) Syndrome in Five Families Isaac Baldwin, Robin L. Shafer, Waheeda A. Hossain, Sumedha Gunewardena, Olivia J. Veatch, Matthew W. Mosconi, Merlin G. Butler> ;International Journal of Molecular Sciences. 2021 Feb 7Prader–Willi Syndrome (PWS, OMIM #176270) is a rare complex genetic disorder due to the loss of expression of paternally derived genes in the PWS critical region on chromosome 15q11-q13. It affects multiple neuroendocrine systems and may present failure to thrive in infancy, but then, hyperphagia and morbid obesity starting in early childhood became the hallmark of this condition. Short ...Figure 1. 15q11.2 BP1-BP2 microdeletion (Burnside Butler) syndrome region found at the proximal end of Prader Willi syndrome (PWS) / Angelman syndrome (AS) regions within the 15q11-q13 Type I deletion depicting the location and order of the four protein-coding genes therein: NIPA1, NIPA2,Burnside-Butler-Syndrom ist ein Name, der auf die Auswirkungen der Mikrodeletion von DNA- Sequenzen angewendet wurde, an denen vier neurologische Entwicklungsgene beteiligt sind ( TUBGCP5 , CYFIP1 , NIPA1 und NIPA2 ). [1] Unterschiedliche Entwicklungsstörungen und psychiatrische Störungen wurden der Mikrodeletion zugeschrieben; die große Mehrheit der Menschen mit der Deletion weist jedoch ...Burnside Butler syndrome or 15q11.2 microdeletion syndrome is a relatively rare chromosomal abnormality that is recently being recognized. Current diagnostic techniques like chromosomal microarray analysis (CMA) have profoundly contributed to currently reported cases. The diagnostic dilemma is that prenatal Systemic inflammatory response syndrome; Systemic inflammatory response syndrome associated with organ dysfunction; Systemic inflammatory response syndrome due to non-infectious process with acute organ failure; ICD-10-CM R65.11 is grouped within Diagnostic Related Group(s) (MS-DRG v 41.0): 864 Fever and inflammatory conditions; Convert …Burnside Butler syndrome or 15q11.2 microdeletion syndrome is a relatively rare chromosomal abnormality that is recently being recognized. Current diagnostic techniques like chromosomal microarray analysis (CMA) have profoundly contributed to currently reported cases. The diagnostic dilemma is that prenatal screening and karyotype analysis typically yield unclear results. We would like to ...The summarised results indicate that chromosome 15q11.2 BP1-BP2 microdeletion is emerging as one of the most common cytogenetic abnormalities seen in individuals with intellectual impairment, autism spectrum disorder and other related behavioural or clinical findings, but more research is needed.Specifically, cytogenetic abnormalities involving the 15q11-q13 region are found in at least 1% of individuals with ASD and include CYFIP1, GABRB3 and UBE3A genes in this chromosome region and most recently the 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome .Background Hereditary spastic paraplegia (HSP) refers to a group of neurodegenerative disorders characterized by bilateral weakness, spasticity, and hyperreflexia in the lower limbs. The autosomal dominant HSP (ADHSP) predominantly presents as the pure form, but the clinical profiles and causal genetic variants underlying ADHSP are complex, and many remain unknown. Methods A cohort of 15 ...The now recognized 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome involves only four genes in the region and can present with cognitive impairment, language and/or motor delay, autism, behavioral problems, poor coordination, ataxia, and congenital anomalies but not with AS or PWS.The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most frequent pathogenic CNV in humans related to neurodevelopmental diseases, with changes in cognition, behavior, and brain morphology .Burnside–Butler syndrome is a name that has been applied to the effects of microdeletion of DNA sequences involving four neurodevelopmental genes (TUBGCP5, CYFIP1, NIPA1, and NIPA2). Varying developmental and psychiatric disorders have been attributed to the microdeletion; however, the great majority of people with the deletion do not have ...Table 5. Literature Review of Other Related Medical Concerns for Individuals with Chromosome 15q11.2 BP1-BP2 Microdeletion Syndrome. - "The 15q11.2 BP1-BP2 Microdeletion Syndrome: A Review"HIV and AIDS are two distinct diseases that can affect humans of all ages. There’s a lot of misinformation out there these viruses. HIV (human immunodeficiency virus) and AIDS (acquired immunodeficiency syndrome) are related, but they are n...Jun 19, 2019 · Magnesium Supplement and the 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: A Potential Treatment? Int J Mol Sci. 2019 Jun 14;20(12): Authors: Butler MG. Abstract The 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome is an emerging disorder that encompasses four genes (NIPA1, NIPA2, CYFIP1, and TUBGCP5). 15q11.2 BP1–BP2 (Burnside-Butler) deletion syndrome: case report and review of the literature Martilias Farrell 1 ,MayaLichtenstein 2 , Matthew K. Harner 3 ,JamesJ.Crowley 1 ,DawnM.Filmyer 3 ,Rafi SK, Butler MG (2020): The 15q11. 2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental ...May 23, 2023 · The aim of this study is to investigate the RNA-binding proteins binding with the four genes present in 15q11.2 BP1-BP2 microdeletion region. The results of this study will help to better understand the molecular intricacies of the Burnside-Butler Syndrome and also the possible involvement of these interactions in the disease aetiology. Nov 5, 2018 · Burnside Butler syndrome or 15q11.2 microdeletion syndrome is a relatively rare chromosomal abnormality that is recently being recognized. Current diagnostic techniques like chromosomal microarray analysis (CMA) have profoundly contributed to currently reported cases. The diagnostic dilemma is that prenatal screening and karyotype analysis ... Magnesium Supplement and the 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: A Potential Treatment? ... Butler MG Int J Mol Sci 2019 Jun 14;20(12) doi: 10.3390/ijms20122914. PMID: 31207912 Free PMC Article. Diagnostic criteria for Rett syndrome. The Rett Syndrome Diagnostic Criteria Work Group. Ann Neurol 1988 Apr;23(4):425-8. doi: 10 ...2 Mar 2021 ... Butler M.G.. The 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome: In silico analyses of the four coding genes reveal functional ...Butler 2019). The region between BP1 and BP2 is approximately 500kb long and is related to Burnside-Butler syn-drome (Burnside et al. 2011; Vanlerberghe et al. 2015; Rafi and Butler 2020). The BP2-BP3 microdeletion is known to be associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) (Rainier et al. 2003; M. G. Butler 2017).Burnside–Butler syndrome is associated with motor and developmental delays, neurobehavioral problems including dyslexia, autism and psychosis with reported congenital anomalies [7,9]. Several of these findings are common in PWS, more so in those with the larger typical deletion.The 15q11.2 BP1–BP2 microdeletion (Burnside-Butler) syndrome is now a recognized condition with over 200 individuals identified from the literature using chromosomal microarray analysis. Clinically, neurological dysfunction, developmental and language delay are the most commonly associated findings followed by motor delay, ADD/ADHD and autism ...Symptoms of burnside-butler syndrome WebThe 15q11.2 BP1–BP2 microdeletion (Burnside-Butler syndrome) was the most common cytogenetic abnormality found in a ...The 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome is an emerging disorder that encompasses four genes (NIPA1, NIPA2, CYFIP1, and TUBGCP5).The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes. Rafi SK, Butler MG Int J Mol Sci 2020 May 6;21(9) doi: 10.3390/ijms21093296.Xem thêm: Ebook Gardner and sutherland's - Chromosome abnormalities and genetic counseling (5/E): Part 2, , Down Syndrome, Other Full Aneuploidies, Polyploidy, and the Influence of Parental Age, A. Ideograms of Human Chromosomes, and Haploid Autosomal Lengths, B. Cytogenetic Abbreviations and Nomenclature, C. Determining 95 Percent ...Abstract: The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most com-mon cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome includeA rare genetic syndromic intellectual disability disease with characteristics of global developmental delay, microcephaly, mild to moderate intellectual disability, truncal ataxia, trunk and limb, or generalised, choreiform movements, and elevated serum creatine kinase levels. Variably associated features include mild cerebral atrophy, muscular weakness or hypotonia in early childhood, and/or ...CMA results revealed a pathogenic 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome 27,28. Our goal in presenting this case summary is to encourage clinicians to consider the possibility that atypical clinical presentations in a context of chronically severe and largely refractory clinical responses might have an identifiable genetic origin ...Those with this small 15q11.2 BP1-BP2 deletion only or having Burnside-Butler syndrome are reported with lower surface area of the brain, a thicker cortex and a smaller nucleus accumbens. Furthermore, regional cortical analyses show localization of the effects to the frontal, cingulate, and parietal lobes.Download scientific diagram | Putative Associated Diseases for the TUBGCP5 Gene. from publication: The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four ...Burnside Butler syndrome or 15q11.2 microdeletion syndrome is a relatively rare chromosomal abnormality that is recently being recognized. Current diagnostic techniques like chromosomal microarray analysis (CMA) have profoundly contributed to currently reported cases. TheIn some cases, like in Burnside-Butler syndrome, the clinical phenotype of the child depends on the origin of parental deletion-if deletion is inherited from the father, there is a higher risk of ...a high probability of resulting in a developmental delay and/or disability (e.g., Down Syndrome, Fragile X Syndrome): Prader Willi Syndrome. Triple X Syndrome. Condition Very Low Birth Weight in addition to: Intraventricular hemorrhage (Grande III or IV) ase (bronchopulmonary dysplasia, BPD) Severe retinopathy of prematurity Cri-du-Chat SyndromeThe 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding... January 2020. Syed Rafi; Merlin Butler; View full-text. Data. Full-text available.The 15q11.2 BP1–BP2 microdeletion (Burnside-Butler) syndrome is now a recognized condition with over 200 individuals identified from the literature using chromosomal microarray analysis. Clinically, neurological dysfunction, developmental and language delay are the most commonly associated findings followed by motor delay, …Genomic, Clinical, and Behavioral Characterization of 15q11.2 BP1-BP2 Deletion (Burnside-Butler) Syndrome in Five Families. Baldwin I, Shafer RL, Hossain WA, Gunewardena S, Veatch OJ, Mosconi MW, Butler MG. Int J Mol Sci, (4):1660 2021 MED: 33562221The genes in the 15q11.2 BP1-BP2 region may contribute to more clinical involvement and comorbidities in those with PWS and Type I deletions, as well as other clinical findings recognized as Burnside-Butler syndrome. ExpandPrader–Willi syndrome and Angelman syndrome molecular analysis workflow. The approach begins with methylation-sensitive MLPA (MS-MLPA) to determine the methylation status and copy number of the 15q11-q13 region (step 1). Based on the results of step 1, proceed to step 2, with whole-exome sequencing (WES) as illustrated in the flowchart for ...Burnside Butler syndrome or 15q11.2 microdeletion syndrome is a relatively rare chromosomal abnormality that is recently being recognized. Current diagnostic techniques like chromosomal microarray analysis (CMA) have profoundly contributed to currently reported cases.Early diagnosis delayed the onset of becoming heavy in individuals with PWS, permitting early GH and other treatment, thus reducing the risk of obesity-associated co-morbidities. Prader-Willi syndrome (PWS) is an imprinting genetic disorder characterized by lack of expression of genes on the paternal chromosome 15q11-q13 region. Growth hormone (GH) replacement positively influences stature ...Butler et al. [14] of behavioral disturbances seen in PWS patients with the larger 15q11–q13 type I deletion compared with the smaller type II deletion which stimulated interest in additional studies of this chromosome region and, hence, coined the Burnside-Butler syndrome.Prader-Willi syndrome (PWS) is a multisystemic complex genetic disorder caused by lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region. There are three main ...Parent-of-origin effects in 15q11.2 BP1-BP2 microdeletion (burnside-butler) syndrome. Int J Mol Sci (2019) S.C. Greenway et al. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet (2009) H. Xie et al.In some cases, like in Burnside-Butler syndrome, the clinical phenotype of the child depends on the origin of parental deletion-if deletion is inherited from the father, there is a higher risk of ...The 15q11.2 BP1-BP2 microdeletion syndrome (or Burnside-Butler syndrome; OMIM # 615656) is a neurodevelopmental disorder with clinical findings reported in hundreds of individuals [1,2]. This condition includes the deletion of four genes thought to be nonimprinted (TUBGCP5, CYFIP1, NIPA1,Burnside–Butler syndrome is a name that has been applied to the effects of microdeletion of DNA sequences involving four neurodevelopmental genes (TUBGCP5, CYFIP1, NIPA1, and NIPA2). Varying developmental and psychiatric disorders have been attributed to the microdeletion; however, the great majority of people with the deletion do not have any …The 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome is emerging as the most frequent pathogenic copy number variation (CNV) in humans associated with neurodevelopmental disorders with ...influences expression of symptoms in Burnside-Butler syndrome, whole-exome sequencing was performed on the parents and affected children for the first time in five families with at least one parent and child with the 15q1l.2 BP1-BP2 deletion. In total, there were 453 genes with possiblyBurnside-Butler syndrome, also known as 15q11.2 BP1-BP2 microdeletion, is a congenital disorder caused by microdeletion of DNA sequences involving four neurodevelopmental genes (TUBGCP5, CYFIP1, NIPA1, NIPA2).It is associated with a number of developmental and psychiatric disorders, however, not all individuals are clinically affected; although more studies are needed to delineate the range of ...HIV and AIDS are two distinct diseases that can affect humans of all ages. There’s a lot of misinformation out there these viruses. HIV (human immunodeficiency virus) and AIDS (acquired immunodeficiency syndrome) are related, but they are n...The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most frequent pathogenic CNV in humans related to neurodevelopmental diseases, with changes in cognition, behavior, and brain morphology .Further phenotypic expansion of 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome. Adria M. Jerkovich, Merlin G. Butler. Frequently Asked Questions About Dr. Jerkovich.The now recognized 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome involves only four genes in the region and can present with cognitive impairment, language and/or motor delay, autism, behavioral problems, poor coordination, ataxia, and congenital anomalies but not with AS or PWS.The now recognized 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome involves only four genes in the region and can present with cognitive impairment, language and/or motor delay, autism, behavioral problems, poor coordination, ataxia, and congenital anomalies but not with AS or PWS.Those individuals with 15q11.2 BP1-BP2 deletions are missing the four genes alone and do not have PWS but have Burnside-Butler syndrome (BBS) (e.g., [27, 38, 39]) with developmental motor and ...Figure 1. 15q11.2 BP1-BP2 microdeletion (Burnside Butler) syndrome region found at the proximal end of Prader Willi syndrome (PWS) / Angelman syndrome (AS) regions within the 15q11-q13 Type I deletion depicting the location and order of the four protein-coding genes therein: NIPA1, NIPA2, Table 3. Literature Review of Intelligence and Academic Achievement for Individuals with Chromosome 15q11.2 BP1-BP2 Microdeletion Syndrome. - "The 15q11.2 BP1-BP2 Microdeletion Syndrome: A Review"The 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome is emerging as a vital pathogenic factor of congenital heart disease [1] and as the most frequent pathogenic copy number variation (CNV ...NIPA1 missense mutation in HSP. A Pedigree of the family. Open circle/square: asymptomatic female/male. Filled circle: affected female. The arrow indicates the proband of this investigation.Parent-of-origin effects in 15q11.2 BP1-BP2 microdeletion (burnside-butler) syndrome. Int J Mol Sci (2019) S.C. Greenway et al. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet (2009) H. Xie et al.The 15q11.2 BP1-BP2 microdeletion syndrome (or Burnside-Butler syndrome; OMIM # 615656) is a neurodevelopmental disorder with clinical findings reported in hundreds of individuals [1,2].In a review of over 10,000 clinically affected individuals tested with ultra-high-resolution chromosome microarrays, the 15q11.2 BP1-BP2 microdeletion …Download scientific diagram | Predicted STRING Protein-Protein Functional Interactions for NIPA1, NIPA2, CYFIP1, and TUBGCP5 Genes. from publication: The 15q11.2 BP1-BP2 Microdeletion (Burnside ...To identify whether parent-of-origin effects (POE) of the 15q11.2 BP1-BP2 microdeletion are associated with differences in clinical features in individuals inheriting the deletion, we collected 71 individuals reported with phenotypic data and known inheritance from a clinical cohort, a research cohort, the DECIPHER database, and the primary literature. Chi-squared and Mann-Whitney U tests were ...In AS, more impaired speech and seizure activity are noted in individuals with the larger deletion [4]. The emerging 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome (BBS) en- compasses the region between the PWS/AS chromosome 15q deletion breakpoints and includes the TUBGCP5, CYFIP1, NIPA1, and NIPA2 genes.Burnside-Butler syndrome is a name that has been applied to the effects of microdeletion of DNA sequences involving four neurodevelopmental genes (TUBGCP5, CYFIP1, NIPA1, and NIPA2). Varying developmental and psychiatric disorders have been attributed to the microdeletion; however, the great majority of people with the deletion do not have any clinical features associated with it.. Discussion. The 15q11.2 BP1-BP2 microdelHer primary diagnosis is Burnside-Butler Syndrome (15q11.2 micr Burnside-Butler syndrome [182, 186]. It was recently ob-served that 15q11.2 deletion patients have structural and . functional changes in the brain that likely relate to the ac- The 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome is now The results of this study will help to better understand the molecular intricacies of the Burnside-Butler Syndrome and also the possible involvement of these interactions in the disease aetiology ...The results of this study will help to better understand the molecular intricacies of the Burnside-Butler Syndrome and also the possible involvement of these interactions in the disease aetiology. The 15q11.2 BP1-BP2 deletion (Burnside-Butler) sy...

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